The Impact of Mold/Fungus on Fertility, Reproduction, and More
Symptoms of mold/fungal exposure have become more prevalent over the last few years, but little research exists on the impacts mold and fungus have on fertility.
Fertility rates have been declining quite readily since the 1960s. With this in mind, how might mold/fungus play a role? This blog post is going to explore the interplay between mold/fungus and fertility, the intricacies of mold/fungus on reproductive function for women and men, the effects mold/fungus may have on your children, and how to detox safely before pregnancy.
What is mold, and what are some common symptoms of mold exposure?
Mold/fungus is a fungus that thrives in damp, warm environments and produces mycotoxins (toxic compounds produced by certain types of molds). Certain types of mycotoxins have been shown to impact fertility and reproductive health, such as ochratoxin A and zearalenone.
Exposure to mold and fungus has been shown to influence leaky gut, uterine fibroids, and hormone regulation. It may contribute to miscarriage risk and endometriosis-like symptoms (such as heavy periods, weight gain, and menstrual irregularity).
Common symptoms of mold exposure include:
Fertility issues
PCOS/Endometriosis symptoms
Heavy periods
Bad PMS
→ May contribute to breast cancer/uterine cancer
Night sweats
Amenorrhea
Underweight
Disruption of thyroid hormone
Disruption in HPA Axis: stress/cortisol cascade
Headaches
Upper respiratory symptoms
How does mold affect hormones?
Mold has been shown to affect hormones in many ways:
Endocrine disruption mimics hormones in the body, disrupts their production, and makes them less responsive to cell signaling so hormones can do their jobs.
Oxidative stress and inflammation—the influx of reactive oxygen species that can lead to cell damage and create inflammation in the body—impact hormone regulation.
HPA axis dysfunction: Mold/fungus exposure has been shown to disrupt the H-P-A axis. Disrupting the production of cortisol (the stress hormone), leading to symptoms such as sugar cravings or weight gain.
Mast cells can be triggered by excessive exposure to mold/fungus. Dr. Tania Dempsey explains that when mold mycotoxins enter the body, alarm bells alert your immune system that it’s in danger and release various chemicals (such as histamine) to protect you. Ongoing exposure can lead to increased inflammation.
How do you distinguish mold symptoms from hormone dysregulation?
Listed below are some of the most common “mold/fungus"-related symptoms:
Upper respiratory infections/symptoms
Chronic cough
Recurring headaches
Fatigue
Neurological issues
Night sweats
If you’re noticing these symptoms along with more typical hormonal issues (like irregular periods or weight gain), mold/fungus exposure might play a role.
Is there a connection to male fertility?
Absolutely. Mold/fungus exposure can affect male fertility in several ways. Certain mycotoxins—like zearalenone (ZEA) and ochratoxin A (OTA)—can disrupt sperm production, lower testosterone, and reduce sperm count. The T-2 toxin can also mess with FSH (follicle-stimulating hormone), which plays a role in progesterone production and fertility.
How does a mold/candida/yeast infection affect my baby's health?
Studies show that mold exposure and even Candida (a type of yeast infection) can impact pregnancy outcomes. Mold/fungus has been linked to:
Low birth weight
Neonatal jaundice
Preterm birth
Is there a correlation to endometriosis? Miscarriages?
Yes, mold/fungus exposure has been linked to endometriosis-like symptoms such as weight gain, heavy periods, and irregular cycles, due to the inflammation caused by mycotoxins. However, there’s not a ton of research connecting mold exposure directly to miscarriage. That said, in my practice, I've seen many women with endometriosis-like symptoms who also have a history of mold/fungus exposure.
Will taking anti-fungal herbs while TTC interfere with conception?
If you’re trying to conceive, I recommend avoiding certain antifungal herbs, especially after ovulation, because they may interfere with fertilization. That said, there are gentle antifungal herbs that can be used earlier in your cycle, but check with your practitioner first before proceeding.
How long before TTC should you cleanse, and when should you stop?
In my practice, I find that at least 6 months to 1 year is ideal to support ahead of conception. If trying to conceive, I would limit exposure to fungal herbs at least 3 months ahead of conception.
How to nourish your body post-infection?
If you suspect you’ve been exposed to mold, it’s important to give your body some support as it detoxes. Gentle detox methods, like herbs, can help clear the toxins. An antifungal diet can also be beneficial. For more detailed information, check out Rain’s Fungal Guide, which offers tips and recommendations for clearing mold exposure.
Disclaimer:
The information presented in this course is intended for educational purposes only, and the Food and Drug Administration hasn’t evaluated it. This information isn’t intended to diagnose, treat, cure, or prevent any condition or disease, nor is it medical advice. The content and material in this course are not personal recommendations or advice. One should consult a qualified medical professional before engaging in any dietary and/or lifestyle change.
*Always check with your doctor before adding new herbs or supplements, especially if you take any medications.
REFERENCES:
1. H. Levine et al., Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update 23, 646-659 (2017).
2. P. Pan et al., Maternal exposure to zearalenone in masculinization window affects the fetal Leydig cell development in rat male fetus. Environ Pollut 263, 114357 (2020).
3. F.A. Gbore, G. N. Egbunike, Testicular and epididymal sperm reserves and sperm production of pubertal boars fed dietary fumonisin B(1). Anim Reprod Sci 105,392-397 (2008).
4 Kościelecka K, Kuć A, Kubik-Machura D, Męcik-Kronenberg T, Włodarek J, Radko L. Endocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins. Toxins (Basel). 2023;15(9):515. Published 2023 Aug 23. doi:10.3390/toxins15090515
5. “Overview of Endocrine Disruption.” EPA, Environmental Protection Agency, www.epa.gov/endocrine-disruption/overview-endocrine-disruption. Accessed 4 Dec. 2024.
6. Watts, Todd. “Symptoms, Diagnosis, and Solutions for Mold Toxicity.” Cellcore Practitioner Dashboard, 7 June 2021, dashboard.cellcore.com/learningcenter/articles/88.
7. Pogrmic-Majkic K, Samardzija Nenadov D, Stanic B, Milatovic S, Trninic-Pjevic A, Kopitovic V, Andric N. T-2 toxin downregulates LHCGR expression, steroidogenesis, and cAMP level in human cumulus granulosa cells. Environ Toxicol. 2019 Jul;34(7):844-852. doi: 10.1002/tox.22752.
8. Doi K, Uetsuka K. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. Int J Mol Sci. 2011;12(8):5213-5237. doi:10.3390/ijms12085213
11 Theoharides, Theoharis C et al. “Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?.” Expert review of clinical immunology vol. 15,6 (2019): 639-656. doi:10.1080/1744666X.2019.1596800
12. Balló, A.; Busznyákné Székvári, K.; Czétány, P.; Márk, L.; Török, A.; Szántó, Á.; Máté, G. Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review. Int. J. Mol. Sci. 2023, 24, 1578.
13. Zheng, W.; Feng, N.; Wang, Y.; Noll, L.; Xu, S.; Liu, X.; Lu, N.; Zou, H.; Gu, J.; Yuan, Y.; et al. Effects of Zearalenone and Its Derivatives on the Synthesis and Secretion of Mammalian Sex Steroid Hormones: A Review. Food Chem. Toxicol Int. J. Publ. Br. Ind. Biol. Res. Assoc. 2019, 126, 262–276.
14. Dempsey, Tania. “What’s the Connection between Mold Illness and Mast Cell Activation?” Dr. Tania Dempsey, 29 Nov. 2023, drtaniadempsey.com/whats-the-connection-between-mold-illness-and-mast-cell-activation/#:~:text=Mold%20and%20Mast%20Cell%20Activation%20Syndrome&text=This%20is%20what%20happens%20when,to%20protect%20you%20from%20harm.